Figure 4. Effect of altered P_TM on vasomotor responses to calcium ionophore A23187 (31.6 to 316 nM) in isolated carotid arteries from neonatal mice .

Arteries were isolated from P7 (top) and P21 (bottom) mice and analysed in a microperfusion system at a P _TM of 20 mmHg and 50 mmHg (P7) or 60 mmHg (P21); 20, 50 and 60 mmHg represent the mean BP of newborn, P7 and P21 mice, respectively (Ishii et al. 2001). Responses are expressed as a percentage of the baseline diameter of the arteries (B) and presented as the mean ± SEM for n = 5. Arteries were stably constricted with U46619 (U4) prior to evaluating the effects of A23187.