Figure 9. Constriction to exogenous ET‐1 (0.3 to 10 nM) in isolated carotid arteries from neonatal mice .

Arteries were isolated from P1 (newborn), P7 and P21 mice and analysed in a microperfusion system at a P _TM of 20 mmHg. Responses are expressed as a percentage of the baseline diameter of the arteries (B) and presented as the mean ± SEM for n = 6 (P1), 7 (P7) or 8 (P21). Arteries were stably constricted with U46619 (U4) prior to evaluating the effects of endothelin‐1.