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. 2016 Sep;24(9):1587–1595. doi: 10.1016/j.joca.2016.05.015

Fig. 3.

Fig. 3

Preventative and therapeutic muMab 911 attenuates the number of TRAP positive osteoclasts in the tibial plateau in MIA rats. (A) The number of TRAP positive osteoclasts in the tibial plateau was significantly increased in MIA rats receiving vehicle treatment. Preventative treatment with muMab 911 significantly reduced the number of TRAP positive osteoclasts in MIA rats. Data are mean ± SEM, n = 9–10 per group. (B) Therapeutic muMab 911 significantly attenuated the MIA-induced increase in the number of TRAP positive osteoclasts in the tibial plateau. Data are mean ± SEM n = 8–10 per group. Statistical comparison was carried out using one-Way ANOVA with Bonferroni's post-hoc tests, *P < 0.05, **P < 0.01. Representative images of osteoclasts at the osteochondral junction of the tibial plateau in a saline-PBS rat (left), MIA-PBS rat (middle) and MIA-muMab 911 rat (right) in the preventative study (C) and therapeutic study (D). Images were taken with a Zeiss Axioplan microscope at 10× magnification. Arrows indicate multinucleated TRAP positive osteoclasts. M911: muMab 911.