Table 2.

Monogenic forms of salt-sensitive hypertension and therapies that effectively reduce blood pressure in these disorders.

Genetic Disorder	Treatment
Liddle syndrome	amiloride, triamterene
Activating MR mutation exacerbated by pregnancy	delivery of fetus amiloride, triamterene,
Apparent mineralocorticoid excess (AME)	MR antagonist, amiloride, triamterene
Gordon syndrome	thiazide diuretic
Glucocorticoid remediable aldosteronism (FH-I, GRA)	glucocorticoids, MR antagonist, amiloride, triamterene
Congenital adrenal hyperplasia (CAH)	adrenalectomy or MR antagonist
Familial hyperaldosteronism not remediable by glucocorticoids (FH-III and FH-IV)	adrenalectomy or MR antagonist

Note: Vasodilators are generally ineffective in treating these disorders that are associated with increased renal tubular NaCl reabsorption