Table 3.

Examples of kidney-specific interventions that prevent or attenuate salt-sensitive increases in blood pressure (BP)

Transplantation of kidney from normotensive human donors normalizes BP in
Patients with apparent mineralocorticoid excess	Kattab et al78
Patients with Liddle’s syndrome	Botero-Velez et al79
Patients with essential hypertension	Curtis et al,80
Transplantation of kidneys from normotensive donor rats reduces/normalizes BP in
Dahl salt-sensitive rats	Dahl et al70
Prague Hypertensive rats	Heller et al72
Milan Hypertensive rats	Bianchi et al71
Spontaneously hypertensive rats	Kawabe et al73
Collecting duct-specific renin deletion attenuates AngII hypertension
	Ramkumar et al84
Distal convoluted tubule-specific deletion of NCC transporter reverses hypertension caused by WNK4 mutations (pseudohypoaldosteronism type II)
	Lalioti et al85
Kidney-specific deletion of TNF-α attenuates AngII hypertension	Zhang et al86
Kidney-specific deletion of AT1 receptors blocks chronic AngII hypertension
	Crowley et al62
Proximal tubule-specific deletion of AT1 receptors attenuates AngII hypertension
	Gurley et al63
Renal denervation lowers blood pressure in
Obese hypertensive humans	DiBona and Esler87
Obese hypertensive experimental animals	Henegar et al88