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. 2015 Jul 21;23(2):339–348. doi: 10.1093/jamia/ocv091

Table 5:

Top orders occurring within 24 h of an order for Spironolactone (Oral), a diuretic commonly used in the management of heart failure and liver cirrhosis.

Rank Description PPV (%) Prevalence (%) Conditional Freq Baseline Freq
1 Metabolic panel, basic 42 77 0.41 2.65
2 Furosemide (Oral) 41 11 0.52 0.31
3 Magnesium, serum 35 52 0.35 1.84
4 Prothrombin time (PT/INR) 35 58 0.35 1.93
5 CBC with differential 31 79 0.28 2.60
6 Potassium chloride (Oral) 28 27 0.34 0.82
7 Furosemide (IV) 27 17 0.35 0.84
8 Pantoprazole (Oral) 24 38 0.19 0.62
9 CBC 24 53 0.20 1.50
10 Sodium chloride (IV) 23 90 0.19 3.97

Results are ranked by PPV (positive predictive value ∼ post-test probability), meaning 41% of patients subsequently receive an order for Furosemide (Oral) (another common diuretic), with an average of 0.52 orders per patient (ConditionalFreq = “Confidence”). Related orders include additional diuretics (Furosemide), monitoring of electrolytes affected by diuresis (Magnesium, Serum), and repletion of lost electrolytes (Potassium Chloride). Notably, many of the orders are the same “best-seller” items that are common overall.