Table 3.

Mutation Rates in Different Genomic Regions of Wild-Type and mutL⁻ Lines.

	Strains	$n_{IG}$	${\mu }_{IG}$	$n_{CDS}$	${\mu }_{CDS}$	$N_{IG}$	$N_{CDS}$	${\mu }_{CDS}/{\mu }_{IG}$	P
Chr1	mutL+	52	7.05	279	4.61	287,564	2,362,343	0.65 (0.48, 0.87)	0.002*
	mutL−	13	18.97	89	15.82	287,564	2,362,343	0.83 (0.47, 1.49)	0.54
Chr2	mutL+	5	5.69	52	5.37	34,289	379,268	0.94 (0.38, 2.35)	0.89
	mutL−	3	4.03	22	2.27	34,289	379,268	0.76 (0.23, 2.54)	0.66
CP1	mutL+	10	31.49	7	8.03	12,391	34,018	0.25 (0.10, 0.66)	0.002*
	mutL−	0	—	1	12.33	12,391	34,018	—	—
MP1	mutL+	9	9.52	23	6.33	36,870	141,790	0.66 (0.31, 1.43)	0.29
	mutL−	1	11.38	4	11.83	36,870	141,790	1.04 (0.12, 9.31)	0.97

Note.—All mutation rates are in units of 10⁻¹⁰ per site per generation. $n_{IG}$, number of mutations in intergenic regions; ${\mu }_{IG}$, intergenic region mutation rate; $n_{CDS}$, number of mutations in coding regions; ${\mu }_{CDS}$, coding region mutation rate; $N_{IG}$, number of intergenic sites; $N_{CDS}$, number of coding sites excluding sites covered by more than one reading frames; numbers in parentheses are 95% confidence intervals from the odds ratio logit method.

*One-sided P values from the odds ratio logit method which shows a significantly lower mutation rate in coding versus intergenic regions, all other P values were from a two-sided odds ratio logit method.