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. 2015 Oct 8;33(1):162–173. doi: 10.1093/molbev/msv208

Fig. 4.

Fig. 4.

Epistatic interaction between Fgf20a and Fgfr1a regulates scale development and is sufficient to phenocopy Phoxinellus scale reduced phenotype. (A) Expression of fgfr1a and fgf20a by whole-mount in situ hybridization in 30-day-old zebrafish. (B) Representative alizarin red-stained zebrafish with loss-of-function mutations in fgf20a (dob) and/or fgfr1a (spd). (C) Average number of scales on lateral flank normalized to the standard length of each fish. ***P value < 0.001. (D) Average area of scales (mm2) in different genetic backgrounds. **P value < 0.01. Error bars represent ±SEM. (E) Model of epistatic interaction between fgfr1a and fgf20a regulating scale number and size.