Table 1.

Clinically-used serum biomarkers for detection of ovarian carcinoma^a

Biomarkers	Sensitivity	Specificity	References
CA125	92%	62%	[17]
RM1 (risk of malignancy index) CA125 + ultrasoundb	96%	82%	[10,17]
HE4	91%	63%	[18]
ROMA (risk of ovarian malignancy algorithm) CA125 + HE4b	95%	77%	[17, 18]
OVA1	96%	40% (pre)c	[19]
5 different markers: (↑CA125; ↑β macroglobulin ↓apolipoprotein A1; ↓prealbumin ↓transferrin)	85%	28% (post)c

^aThe sensitivity and specificity values are for differentiating benign diseases from OvCa.

^bThe menopausal status influences risk. The values shown are for all patients without consideration of the menopausal status.

^cPre vs. post refer to pre-menopause and post-menopause