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. Author manuscript; available in PMC: 2016 Sep 2.
Published in final edited form as: Neuropharmacology. 2014 Feb 12;87:188–197. doi: 10.1016/j.neuropharm.2014.02.002

Figure 2. Effect of chronic METH withdrawal on exploratory activity.

Figure 2

Mice were treated with vehicle or METH (1 mg/Kg, sc, once a day for 7 days), and on withdrawal were placed in an open-top arena in a 5 min habituation session for 3 consecutive days. A) Locomotion, *: Day 1 different from Day 2 and Day 3 (p<0.05). B) Time in center, *: vehicle different from METH in Day 2. Exploratory activity during METH withdrawal was evaluated using Ethovision XT 7.0 tracking software (Noldus, Leesburg, Virginia). Repeated measures two-way ANOVA - Bonferroni. Values indicate mean ± SEM (N=8–9),