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. Author manuscript; available in PMC: 2016 Sep 2.
Published in final edited form as: Neuropharmacology. 2014 Feb 12;87:188–197. doi: 10.1016/j.neuropharm.2014.02.002

Figure 5. Effect of modafinil on METH-induced changes in ERK phosphorylation in the mPFC after novelty exposure.

Figure 5

On withdrawal day 4 after chronic vehicle or METH treatment (1 mg/Kg, sc, once a day for 7 days) mice received acute MOD and 1 hr later performed a 10 min novelty session, then euthanized immediately (novelty group). Control mice were placed in the arena in the absence of objects and the same procedure was performed (control group). A) Modafinil 30 mg/Kg. B) Modafinil 90 mg/Kg. Two way ANOVA followed by planned contrasts between control and novelty within each treatment. Values indicate the mean ± SEM (N=4–9), *: significantly different from control of the respective treatment.