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. Author manuscript; available in PMC: 2016 Sep 2.
Published in final edited form as: Neuropharmacology. 2014 Feb 12;87:188–197. doi: 10.1016/j.neuropharm.2014.02.002

Figure 6. Effect of MOD on METH-induced changes in ERK phosphorylation in the hippocampus and nucleus accumbens (NAc) after novelty exposure.

Figure 6

On withdrawal day 4 after chronic vehicle or METH treatment (1 mg/Kg, sc, once a day for 7 days) mice received acute modafinil 90 mg/Kg and 1 hr later performed a 10 min novelty session, then were euthanized immediately (novelty group). Control mice were placed in the arena in the absence of objects and the same procedure was performed (control group). A) Hippocampus, B) Nucleus accumbens (NAc). Two way ANOVA. Values indicate the mean ± SEM (N=3–5).