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(A) Viability of A2780cis or HS-5 cell lines incubated with 12.5 μM of 1a or 1b for 48 h. (B) Viability of A2780cis treated by 1a (12.5 μM) in the presence of phosphatase inhibitors or cell death signaling inhibitors at 48h ([l-Phe] = [levamisole] = 1 mM, [ALP] = 1 U/mL, [zVAD-fmk] = 45 μM, [PJ34] = 1 μM, [Nec-1] = 50 μM). (C, D) Confocal images of A2780cis cells treated with anti-DR5 (C) without or (D) with the addition of 1a (12.5 μM) for 24 h. Scale bar = 30 μm.
