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. Author manuscript; available in PMC: 2016 Sep 2.
Published in final edited form as: Nat Microbiol. 2016 Apr 4;1:16031. doi: 10.1038/nmicrobiol.2016.31

Figure 5. PneumotypeSPT is associated with a blunted TLR4 response of alveolar macrophages.

Figure 5

Alveolar macrophages of subjects with pneumotypeSPT or pneumotypeBPT were cultured for 24 h and exposed to 10 ng LPS or media alone. Cytokine production was compared for LPS/MA to calculate fold induction. Average UniFrac distances between pairs of BAL samples and upper airways correlated to fold induction of MDC, IL-6 and GM-CSF. Red symbols represent BAL samples identified as pneumotypeSPT and green symbols represent BAL samples identified as pneumotypeBPT (lines represent median and SE, P value based on Spearman’s ρ).