Table 1.
Demographics and pulmonary function.
| Cohort | PneumotypeBPT | PneumotypeSPT | P-value | |
|---|---|---|---|---|
| n | 49 | 27 | 22 | |
| Cohort (%) | NS | |||
| NYU | 63 | 64.5 | 35.5 | |
| OSU | 8 | 75 | 25 | |
| LHMP | 29 | 26.8 | 71.4 | |
| Age (years) | 53.0 (39.8–63.4) | 52.3 (36.8–62.7) | 55.0 (43.4–65.0) | NS |
| Male (%) | 64 | 63 | 77 | NS |
| Caucasian (%) | 77 | 81 | 91 | NS |
| BMI | 27 (23–31) | 26 (23–31) | 27 (24–31) | NS |
| Smoking status (%) | ||||
| Current | 26 | 33 | 18 | NS |
| Former | 37 | 33 | 41 | NS |
| Never | 37 | 33 | 41 | NS |
| Pack-years (smokers) | 25 (5–43) | 25 (5–43) | 39 (19–49) | NS |
| PFT* | ||||
| Spirometry | ||||
| FVC† | 98.0 (89.5–115.0) | 100.0 (91.7–116.0) | 98.9 (86.8–108.5) | NS |
| FEV1† | 90.0 (81.0–108.0) | 92.9 (85.5–100.0) | 90.0 (78.9–104.7) | NS |
| FEV1 /VC | 75.0 (67.0–79.7) | 75.5 (69.0–80.0) | 74.0 (68.9–79.6) | NS |
| Lung volumes | NS | |||
| TLC† | 100 (85–107) | 99 (85–107) | 100 (80–107) | NS |
| FRC† | 87 (75–107) | 86 (75–108) | 90 (75–106) | NS |
| RV/TLC | 0.32 (0.26–0.37) | 0.32 (0.23–0.36) | 0.34 (0.30–0.40) | NS |
| DLCO† | 84 (75–94) | 90 (72–96) | 82 (77–92) | NS |
Data presented as percentages or median (IQR). P-value for comparison between pneumotypeBPT vs pneumotypeSPT. Abbreviations: NYU, New York University; OSU, Ohio State University; LHMP, Lung HIV Microbiome Project; BMI, body mass index; FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; TLC, total lung capacity; FRC, functional residual capacity; RV, residual volume; DLCO, diffusing capacity of the lungs for carbon monoxide; NS, not significant.
*
PFT, pulmonary function testing according to standard ATS/ERS guidelines20
†
% predicted.