. 2016 Aug 8;18(16):4128–4131. doi: 10.1021/acs.orglett.6b02082

Table 2. Summary of Reaction Optimization by DOE:^a (A) Initial Analysis of 11 Reaction Variables; (B) Subsequent Analysis of Four Reaction Variables.

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For categorical variables, highest yield/ee obtained with listed entry. For continuous variables: 0 = variable has no effect on yield/ee, + = highest yield/ee obtained at highest value of variable, – = highest yield/ee obtained at lowest value of variable.

Table 2. Summary of Reaction Optimization by DOE:a (A) Initial Analysis of 11 Reaction Variables; (B) Subsequent Analysis of Four Reaction Variables.

Table 2. Summary of Reaction Optimization by DOE:^a (A) Initial Analysis of 11 Reaction Variables; (B) Subsequent Analysis of Four Reaction Variables.