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. Author manuscript; available in PMC: 2016 Dec 6.
Published in final edited form as: Nat Microbiol. 2016 Jun 6;1(8):16078. doi: 10.1038/nmicrobiol.2016.78

Figure 3. Influence of Rv0880 overexpression on Excess over Bliss estimation of bedaquiline and pretomanid drug combination.

Figure 3

The Excess over Bliss (EOB) estimation for all bedaquiline and pretomanid (BPa) combinations tested with induced (magenta) and un-induced (blue) rv0880 overexpression cultures. Error bars represent the standard deviation of EOB, estimated from three biological samples. The dashed gray line is at EOB = 0 (additive) and represents a line over and below which BPa combinations are considered synergistic and antagonistic, respectively. This experiment was repeated twice with reproducible results. Bedaquiline, B. Pretomanid, Pa.