Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 2;6:32298. doi: 10.1038/srep32298

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(a) Workflow for the computational inference of pCSM loci. (b) Methylation pattern of a predicted CSM loci (Chr5:149675541-149675604) at 6,138 bp upstream of CAMK2A gene in 25 yr brain methylome. (c) In situ hybridization for CAMK2A in human prefrontal cortex showing positive staining in the excitatory neurons in layers II-VI with absent staining in the glial cells (modified from Allen Brain Atlas; http://human.brain-map.org/ish/specimen/show/80936541?gene=811). (d) Changes of mC level in CG and CH context and the percentage of CSM segments after down-sampling normalization during human brain development. (e) Hierarchical clustering based on Pearson’s correlations of pCSM statuses predicted for 4-CpG segments in different human brain methylomes.