Table 1.
Comparison of clinicopathological and treatment characteristics of patients with differentiated thyroid carcinoma aged below 60 years and above 60 years at presentation
| Variables | Aged below 60 years (n=252) | Aged above 60 years (n=118) | P-value |
|---|---|---|---|
| Age (years) | |||
| Median (range) SD | 51.9 (46–60) ±4.2 | 68.6 (62–97) ±565.2 | 0.022 |
| Sex, n (%) | |||
| M | 50 (19.8) | 28 (12.3) | |
| F | 202 (74.1) | 90 (87.7) | 0.235 |
| Tumor size (cm) | |||
| Median (range) SD | 2.92 (0.3–11) ±1.97 | 2.88 (0.2–10) ±1.87 | 0.653 |
| Histology, n (%) | |||
| Papillary | 235 (93.3) | 109 (92.4) | 0.063 |
| Classic | 149 (63.4) | 46 (42.2) | 0.003 |
| Follicular | 63 (26.8) | 44 (40.2) | 0.002 |
| Tall cell | 18 (7.6) | 13 (11.9) | 0.041 |
| Sclerosing | 5 (2.2) | 6 (5.5) | 0.044 |
| Follicular | 17 (6.7) | 9 (7.6) | 0.065 |
| T stage, n (%) | |||
| T1 | 70 (27.8) | 28 (23.7) | |
| T2 | 106 (42.1) | 36 (30.5) | 0.018 |
| T3 | 62 (24.5) | 47 (39.9) | |
| T4 | 14 (5.6) | 7 (5.9) | |
| N stage, n (%) | |||
| N0 | 184 (73.1) | 67 (56.9) | |
| N1 | 68 (26.9) | 51 (43.2) | 0.002 |
| N1a | 30 (44.2) | 30 (58.8) | |
| N1b | 38 (55.8) | 21 (41.2) | |
| M stage, n (%) | |||
| M0 | 242 (96.0) | 105 (88.9) | 0.010 |
| M1 | 10 (4.0) | 13 (11.0) | |
| Multifocality, n (%) | |||
| Yes | 76 (30.2) | 52 (44.1) | 0.006 |
| No | 176 (69.8) | 66 (55.9) | |
| LVSI, n (%) | |||
| Yes | 63 (25.0) | 48 (40.7) | 0.003 |
| No | 189 (75.0) | 70 (59.3) | |
| Surgery, n (%) | |||
| Total thyroidectomy | 215 (85.3) | 99 (83.9) | |
| Near total thyroidectomy | 37 (14.7) | 19 (16.1) | 0.065 |
| Neck dissection, n (%) | |||
| No | 46 (18.2) | 38 (32.2) | |
| Yes | 206 (81.7) | 80 (67.8) | 0.027 |
| Central | 104 (50.5) | 48 (60.0) | |
| Lateral | 102 (49.5) | 32 (40.0) | |
| Adjuvant RAI therapy, n (%) | |||
| No | 35 (13.9) | 9 (6.9) | |
| Yes | 217 (84.9) | 109 (89.8) | 0.460 |
| 30 mCi | 41 (18.9) | 15 (13.7) | |
| 100 mCi | 48 (22.1) | 21 (19.3) | |
| 150 mCi | 117 (53.9) | 58 (53.3) | |
| 200 mCi | 11 (5.1) | 15 (13.7) | |
Note: Data in bold indicates statistical significance.
Abbreviations: n, number; DTC, differentiated thyroid cancer; SD, standard deviation; M, male; F, female; T, tumor; N, node; M, metastasis; LVSI, lymphovascular space invasion; RAI, radioactive iodine; mCi, millicurie.