Table 2.
Assessment of insulin, C-peptide, DPP-IV pathway, inflammatory, and oxidant variables in various experimental groups
| SN | Name of parameter | Insulin (µU/ml) | C-peptide (ng/ml) | HOMA-IR | HOMA-β | Serum DPP-IV (λU/mL) | hs-CRP (mg/dL) | MDA (nmol/mL) |
|---|---|---|---|---|---|---|---|---|
| 1 | NC | 6±0.6 | 0.07±0.02 | 1.57 | 66.6 | 4.76±0.43 | 0.86±0.07 | 1.84±0.08 |
| 2 | HF-DC | 2.93±1.11 | 0.05±0.03 | 2.17 | 5.9 | 44.53±4.5 | 2.2±0.5 | 6.07±0.66 |
| 3 | MET | 4.33±1.2** | 0.07±0.02 | 1.64 | 17.2* | 28.45±2.9** | 1.68±0.31* | 4.25±0.43* |
| 4 | VIL | 4.73±0.31** | 0.06±0.03 | 1.79 | 18.37* | 12.32±1.02***,$ | 0.94±0.16* | 4.09±0.46* |
| 5 | MNG | 4.13±0.4** | 0.07±0.01 | 1.6 | 17.08* | 15.26±1.8***,$ | 1.01±0.24* | 3.31±0.21** |
Notes: NC (n=8), HF-DC (n=7), MET (n=8), VIL (n=8), and MNG (n=7). Values are expressed as mean ± SD.
*
significant P<0.05,
**
P<0.01,
***
P<0.001 vs HF-DC.
$
P<0.05 vs MET.
Abbreviations: DPP-IV, dipeptidyl peptidase-IV; HOMA-β, homeostasis model assessment-β; HOMA-IR, homeostasis model assessment of insulin resistance; hs-CRP, high-sensitivity C-reactive protein; MDA, malondialdehyde; NC, normal control; HF-DC, high-fat diabetic control; MET, metformin; VIL, vildagliptin; MNG, mangiferin; SN, serial number; λU/mL, micro unit/ml.