. Author manuscript; available in PMC: 2016 Oct 21.

Published in final edited form as: Eur J Med Chem. 2016 Jul 9;122:786–801. doi: 10.1016/j.ejmech.2016.07.010

Table 1.

IC₅₀ values of the Gewald products in which tail on the amide in the 3-position was varied.

Compound	R²	IC₅₀ (µM)
C6	H	20.6 ± 3.8
C2	H	18.6 ± 6.0
A9	H	12.4 ± 0.9
3a	H	17.9 ± 5.6
3b	H	41.5 ± 19.6
3c	H	47.3 ± 14.8
3d	H	>50
3e		>50