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. 2016 Aug 29;11:4141–4155. doi: 10.2147/IJN.S109494

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© 2016 Key et al. This work is published and licensed by Dove Medical Press Limited

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pMCNPs were evaluated for 3T GE MRI and ICP-MS. pMCNPs solutions were serially diluted in a 96-well plate and imaged by GE MRI.

Notes: A lower number of pMCNPs had a brighter MR signal, which clearly demonstrated that T₂ contrast effects depended on the pMCNP concentration (A). The total amount of Fe in pMCNPs directly influenced the MR signal (B). At longer echo times the hydrogen atoms were dephased by the particles faster, indicating the T₂ contrast effects of pMCNPs (C). The r₂ value (180.7 mM⁻¹s⁻¹) of pMCNP was calculated by ICP-MS and 3T GE MRI. The r₂ value was higher than that of commercialized products, such as Feridex (120 mM⁻¹s⁻¹)⁹ (D).

Abbreviations: CNPs, chitosan nanoparticles; ICP-MS, inductively coupled plasma mass spectrometry; NCs, nanocubes; pMCNPs, peptide-conjugated chitosan nanoparticles; MR, magnetic resonance; MRI, magnetic resonance imaging; TEs, echo times; GE, General Electric.