Table 2.

Common mutations of APP affecting secretase activities with giving the site of mutation and amino acid change.

APP Mutation	Amino Acid Change		Site of Mutation (APP Amino Acid Number)
Swedish	K > N M > L	Lysine > Asparagine Methionine >Leucine	670 671
DN	A > V	Alanine > Valine	673
English	H > R	Histidine > Arginine	677
Tottori	D > N	Aspartic acid > Asparagine	678
Taiwanese	D > H	Aspartic acid > Histidine	678
Leuven (Italian)	E > K	Glutamic acid > Lysine	682
Flemish	A > G	Alanine >Glycine	692
Arctic	E > G	Glutamic acid > Glycine	693
Italian	E > K	Glutamic acid > Lysine	693
Dutch	E > Q	Glutamic acid > Glutamine	693
Iowa	D > N	Aspartic acid > Asparagine	694
Austrian	T > I	Threonine >Isoleucine	714
Iranian	T > A	Threonine > Alanine	714
German	V > A	Valine > Alanine	715
French	V > M	Valine > Methionine	715
Florida	I > V	Isoleucine > Valine	716
Indiana	V > F	Valine > Phenylalanine	717
London	V > I	Valine > Isoleucine	717
---------	V > L	Valine > Leucine	717