Table 3.

Dose Adjustments for CYP450 Considerations⁶

Concomitant Drug	Dose Change for Aripiprazole Lauroxila
Strong CYP3A4 inhibitor	Reduce the dose of aripiprazole lauroxil to the next lower strength. No dosage adjustment is necessary in patients taking 441 mg aripiprazole lauroxil, if tolerated. For patients known to be poor metabolizers of CYP2D6: Reduce dose to 441 mg from 662 mg or 882 mg. No dosage adjustment is necessary in patients taking 441 mg aripiprazole lauroxil, if tolerated.
Strong CYP2D6 inhibitor	Reduce the dose of aripiprazole lauroxil to the next lower strength. No dosage adjustment is necessary in patients taking 441 mg aripiprazole lauroxil, if tolerated. For patients known to be poor metabolizers of CYP2D6: No dose adjustment required.
Both strong CYP3A4 inhibitor and strong CYP2D6 inhibitor	Avoid use for patients at 662-mg or 882-mg dose. No dosage adjustment is necessary in patients taking 441 mg aripiprazole lauroxil, if tolerated.
CYP3A4 inducer	No dose adjustment for 662-mg and 882-mg dose, but increase the 441-mg dose to 662 mg.

^aFor the 882-mg dose administered every six weeks, the next lower strength should be 441 mg administered every four weeks.