Table 4.
Odds ratio (OR) and 95% confidence interval (CI) for placental abruption in relation to categories of weighted genetic risk score (wGRS) computed from candidate circadian rhythm genes SNPs selected in multivariable analyses
| Circadian Rhythm Genes Weighted Genetic Risk Score (wGRS) | Median of WGRS | Placental Abruption (N=470) | Controls (N=473) | Unadjusted OR (95%CI) | Adjusted OR* (95%CI) |
|---|---|---|---|---|---|
|
| |||||
| n (%) | n (%) | ||||
| Quartile 1 (<23.80) | 23.4 | 45 (9.6) | 118 (25.0) | 1.00 (referent) | 1.00 (referent) |
| Quartile 2 (23.81–24.29) | 24.1 | 84 (17.9) | 119 (25.2) | 1.85 (1.19–2.88) | 1.83 (1.10–3.06) |
| Quartile 3 (24.30–24.74) | 24.5 | 116 (24.7) | 117 (24.7) | 2.60 (1.69–3.99) | 2.81 (1.71–4.60) |
| Quartile 4 (≥24.75) | 25.1 | 225 (47.9) | 119 (25.2) | 4.96 (3.29–7.46) | 5.13 (3.21–8.21) |
| P-value for linear trend | <0.001 | <0.001 | |||
| Quartile 1 (<23.80) | 23.4 | 45 (9.6) | 118 (25.0) | 1.00 (referent) | 1.00 (referent) |
| ≥90% decile (≥25.10) | 25.4 | 132 (28.1) | 49 (10.4) | 7.06 (4.39–11.36) | 6.97 (4.10–11.85) |
*
Adjusted for maternal age, smoking during pregnancy, preeclampsia status and gestational age at delivery