Table 3.

Multivariate analysis of CA125, HE4, FOLR1, and KLK6 for the diagnosis of ovarian cancer cases.

Marker	AUC (95% CI)				Sensitivity (95% CI) at set specificity of:
	Spanish cohort	American cohort	Canadian cohort	All cohorts	95%	99%
CA125	0.91 (0.84–0.96)	0.80 (0.66–0.93)	0.74 (0.67–0.80)	0.82 (0.78–0.86)	35.6% (19.4–49.0)	19.0% (10.2–31.5)
CA125 + HE4	0.94 (0.88–0.98)	0.79 (0.66–0.91)	0.79 (0.74–0.85)	0.85 (0.81–0.89)	67.1% (38.4–58.8)	37.0% (9.7–56.9)
CA125 + FOLR1	0.91 (0.84–0.97)	0.83 (0.69–0.93)	0.74 (0.69–0.81)	0.83 (0.79–0.87)	56.9% (34.7–63.9)	30.1% (14.9–46.4)
CA125 + KLK6	0.91 (0.83–0.97)	0.83 (0.69–0.94)	0.73 (0.66–0.80)	0.82 (0.78–0.86)	38.4% (24.9–52.3)	25.5% (16.2–39.3)
All	0.92 (0.86–0.98)	0.86 (0.74–0.97)	0.79 (0.74–0.85)	0.85 (0.82–0.89)	51.9% (43.1–63.9)	38.4% (16.6–62.0)
HE4 + FOLR1	0.89 (0.83–0.96)	0.84 (0.71–0.93)	0.79 (0.73–0.85)	0.83 (0.80–0.87)	64.8% (40.3–61.6)	38.8% (17.5–63.8)

All models are age-adjusted