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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: J Mol Biol. 2016 Jul 31;428(17):3467–3482. doi: 10.1016/j.jmb.2016.07.017

Figure 5. Mechanisms of NNSV mediated inhibition of IFN induction.

Figure 5

A. The non-structural proteins NS1 and NS2 from respiratory syncytial virus (RSV) interact with MAVS and RIG-I, respectively, to disrupt RLR signaling. B. Measles virus (MeV) V protein binds to protein phosphatase 1 α/γ (PP1α/γ) and inhibits dephosphorylation and activation of RLRs. C. Ebolavirus VP35 (EBOV VP35) protein binds to PACT and inhibits PACT-induced activation of RIG-I. D. Filoviral VP35 proteins bind to kinases TBK1 and IKKe and act as decoy substrates to inhibit the phosphorylation of IRF3/7. Paramyxoviral V protein and Bornavirus and Rhabdovirus P protein also inhibit IRF3/7 phosphorylation in a similar manner.