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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: J Mol Biol. 2016 Jul 31;428(17):3467–3482. doi: 10.1016/j.jmb.2016.07.017

Figure 7. Inhibition of the JAK/STAT pathway by EBOV VP24.

Figure 7

A. Crystal structure of EBOV VP24 (red) in complex with ARM 7–10 of KPNA5 (dark blue) (PDB 4U2X) [76]. ARM 7–10 is aligned to the structure of full length KPNA (cyan) (PDB 1BK5) [77] as reference. B. Model showing how EBOV VP24 targets the non-classical nuclear localization signal (ncNLS) recognition of KPNA and blocks nuclear accumulation of pY-STAT1 while leaving classical NLS interactions intact.