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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: J Mol Biol. 2016 Jul 31;428(17):3467–3482. doi: 10.1016/j.jmb.2016.07.017

Figure 8. Viral modulation of host ubiquitination.

Figure 8

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A. Cartoon model depicting the mechanism of SV5 V protein mediated ubiquitination of STAT2. B. Crystal structure of the complex of SV5 V protein (red), DDB1 (green), Cullin4 (grey), and Rbx1 (Blue) (PDB 2HYE) [118]. BPB of DDB1 binds to the N-terminal domain of Cullin4, while Rbx1 binds to the C-terminal domain of Cullin4. C. Crystal structure of Simian virus 5 (SV5) V protein (red) and DDB1 (green) showing the three β-propellers BPA, BPB, and BPC (PDB 2B5l) [117]. The SV5 V protein binds at a pocket within the BPA and BPC. D. Close up of the V binding pocket. N-terminal helix α1 of V protein inserts into the hydrophobic pocket of DDB1. Tyr127 of V protein makes important inter-subunit interactions with BPC.