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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Clin Cancer Res. 2016 Apr 8;22(17):4350–4355. doi: 10.1158/1078-0432.CCR-15-3163

Table 2.

One-sided logistic regression in the validation cohort to test whether the direction of association found in the exploratory cohort can be confirmed.

SNP ORglobal (95% CI) P P pointwise P FWER
rs10862339 1.02 (0.58-1.79) 0.53 0.54 0.96
rs1344016 1.05 (0.60-1.85) 0.43 0.44 0.91
rs2414277 1.20 (0.71-2.08) 0.24 0.22 0.66
rs2839629 2.04 (1.11-3.33) 9.6 × 10−3 8.3 × 10−3 0.036
rs4776196 1.19 (0.71-2.08) 0.24 0.27 0.70
rs11145770 1.43 (0.75-2.33) 0.14 0.13 0.46

ORglobal = the estimated odds ratio by logistic regression; P = uncorrected parametric P value; Ppointwise = pointwise P value as determined by permutation; PFWER = permuted P value (family wise error rate correction).