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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Cancer Discov. 2016 Jul 17;6(9):1052–1067. doi: 10.1158/2159-8290.CD-15-1227

Figure 1.

Figure 1

Manhattan plot of results from the combined breast, ovarian, and prostate cancer meta-analysis. The black and gray dots represent the 2,231 variants nominally associated (P < 0.05) with every cancer type individually that had the same direction of effect across all three cancers. The red line corresponds to a threshold of P = 10−8. Eighteen independent loci were identified at this threshold. The green dots highlight index SNPs at 11 loci out of these 18 where model selection using ASSET confirmed contribution from all three cancer types to the association signal and that remained at P < 10−8 after adjusting for the controls shared between the breast and ovarian cancer studies. Gene names identify the three loci out of the 11 that were > 1 Mb away from previously identified index SNPs for any of the three cancers.