Table 1.
Comparison of Serum and FF Immunoassay Results: Stratified by Study Group and Also by BMI, Controls Versus PCOS and Lean (BMI < 25) Versus Overweight (BMI ≥ 25 kg/m2)
| Controls (n = 26) | PCOS (n = 22) | P Value | Lean (n = 31) | Overweight (n = 17) | P Value | |
|---|---|---|---|---|---|---|
| Age, y | 31.8 ± 6.4 | 30.4 ± 4.3 | NSa | 31.7 ± 6.0 | 30.4 ± 4.9 | NSa |
| BMI, kg/m2 | 23.8 ± 5.3 | 25.9 ± 4.9 | NSa | 21.8 ± 2.1 | 30.1 ± 4.7 | na |
| Serum AMH, ng/mL | 3.0 (1.0, 3.8) | 6.4 (4.6, 8.2) | <.00001b | 3.8 (1.9, 5.1) | 4.5 (2.8, 6.4) | NSb |
| HOMA-IR | 1.4 ± 0.93 | 1.4 ± 0.95 | NSb | 0.9 ± 0.49 | 2.0 ± 0.95 | .006b |
| Serum CRP, mg/L | 3.4 (1.7, 6.6) | 2.5 (1.5, 10.1) | NSb | 2.1 (1.3, 6.2) | 4.7 (2.2, 8.8) | NSb |
| Serum TNFα, pg/mL | 0.87 ± 0.11 | 0.88 ± 0.14 | NSa | 0.87 ± 0.13 | 0.88 ± 0.14 | NSa |
| Serum IL-6, pg/mL | 1.56 ± 1.16 | 1.40 ± 0.73 | NSb | 1.31 ± 1.03 | 1.66 ± 0.69 | .046b |
| Serum T, ng/dL | 36.0 (21.6, 60.8) | 55.0 (38.2, 98.0) | NSb | 35.5 (21.6, 51.4) | 66.7 (42.5, 102.6) | .02b |
| FAI | 0.70 (0.58, 0.90) | 2.11 (1.23, 2.77) | .009b | 0.70 (0.58, 1.01) | 2.11 (1.33. 3.01) | .003b |
| FF IL-6, pg/mL | 6.4 (5.0, 10.8) | 8.4 (6.7, 24.2) | .07b | 7.3 (5.1, 12.4) | 8.4 (6.4, 13.0) | NSb |
| FF CRP, mg/L | 1.36 (0.53, 3.64) | 1.90 (0.57, 4.12) | NSb | 1.25 (0.56, 2.98) | 3.97 (0.56, 7.94) | NSb |
| FF TNFα, pg/mL | 0.72 ± 0.16 | 0.64 ± 0.13 | NSa | 0.70 ± 0.15 | 0.58 ± 0.04 | NSa |
| FF IL-8, pg/mL | 118.0 (46.3, 177.7) | 122.3 (94.3, 165.6) | NSb | 114.4 (66.0, 163.4) | 130.1 (81.3, 221.3) | NSb |
| FF T, ng/dL | 648 (425, 922) | 523 (467, 674) | NSb | 515 (413, 816) | 726 (523, 979) | .08b |
| FF Estradiol, pg/mL | 210 070 (81 300; 370 205) | 148 305 (73 464; 293 540) | NSb | 145 045 (73 324; 348 735) | 293 540 (148 305; 370 205) | NSb |
Abbreviations: AMH, antimullerian hormone; BMI, body mass index; na, not applicable; NS, nonsignificant. Data are shown as mean ± SD or median (interquartile range).
a
Comparison with a two-sample t test.
b
Comparison with a Mann-Whitney test.