Table 3.
Time to select liver chemistry (LC) elevation events in Altos and Veteran Affairs databases
| Drug | LC elevation | Altos | Veteran Affairs | ||
|---|---|---|---|---|---|
| No. events | Mean (median) days to event | No. events | Mean (median) days to event | ||
| Pazopanib | ALT ≥3x ULN | 7 | 82.7 (61) | 23 | 149 (56) |
| Total bilirubin ≥2x ULN | 3 | 73.3 (38) | 6 | 311 (382) | |
| Possible Hy’s law | 0 | NA | 0 | NA | |
| Bevacizumab | ALT ≥3x ULN | 7 | 84.4 (84) | 3 | 236 (218) |
| Total bilirubin ≥2x ULN | 1 | 112 (112) | 2 | 97 (97) | |
| Possible Hy’s law | 0 | NA | 0 | NA | |
| Sorafenib | ALT ≥3x ULN | 3 | 57 (60) | 6 | 160 (89) |
| Total bilirubin ≥2x ULN | 1 | 28 (28) | 10 | 135 (57) | |
| Possible Hy’s law | 0 | NA | 1 | 162 (162) | |
| Sunitinib | ALT ≥3x ULN | 8 | 79.1 (82.5) | 18 | 96 (41) |
| Total bilirubin ≥2x ULN | 3 | 60.7 (77) | 30 | 71 (41) | |
| Possible Hy’s law | 0 | NA | 2 | 31 (31) | |
Possible Hy’s law: the combination of LC elevations indicative of possible Hy’s law was defined as ALT or AST ≥3x ULN, total bilirubin ≥2x ULN and ALP <2x ULN
ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, ULN upper limit of normal