Table 2.
Reliability of estimates of regional tracer distribution volume (V T)
| Region | Test | Retest | % relative difference | TRV | COV (%) test | COV (%) retest | ICC |
|---|---|---|---|---|---|---|---|
| Whole brain | 1.11 ± 0.12 | 1.15 ± 0.14 | 2.99 ± 5.43 | 4.2 ± 3.9 | 11.0 | 12.0 | 0.94 |
| Amygdala | 0.84 ± 0.08 | 0.90 ± 0.10 | 6.60 ± 8.57 | 8.6 ± 4.9 | 9.0 | 11.3 | 0.74 |
| Caudate putamen | 1.29 ± 0.17 | 1.32 ± 0.20 | 2.43 ± 4.85 | 3.6 ± 3.6 | 13.1 | 15.4 | 0.97 |
| Mesencephalic region | 1.07 ± 0.10 | 1.10 ± 0.16 | 2.58 ± 7.88 | 6.0 ± 4.8 | 9.7 | 14.5 | 0.88 |
| Pons | 0.93 ± 0.07 | 0.97 ± 0.11 | 4.49 ± 8.29 | 7.3 ± 4.7 | 7.6 | 10.8 | 0.73 |
| Medulla | 0.88 ± 0.07 | 0.92 ± 0.10 | 5.24 ± 9.39 | 8.5 ± 5.0 | 8.3 | 10.8 | 0.65 |
| Cerebellum | 1.17 ± 0.11 | 1.22 ± 0.11 | 4.25 ± 6.28 | 4.6 ± 5.3 | 9.7 | 8.8 | 0.87 |
| Olfactory bulb | 0.66 ± 0.10 | 0.69 ± 0.13 | 4.00 ± 7.79 | 6.0 ± 5.3 | 15.1 | 19.3 | 0.93 |
| Cortex | 1.11 ± 0.14 | 1.13 ± 0.14 | 1.86 ± 4.59 | 3.2 ± 3.3 | 12.9 | 12.8 | 0.97 |
| Hippocampus | 1.23 ± 0.11 | 1.28 ± 0.14 | 3.85 ± 6.88 | 6.2 ± 3.9 | 9.1 | 10.7 | 0.86 |
| Hypothalamus | 0.89 ± 0.08 | 0.95 ± 0.13 | 6.76 ± 9.67 | 9.4 ± 5.1 | 8.6 | 13.2 | 0.71 |
| Thalamus | 1.39 ± 0.17 | 1.43 ± 0.18 | 2.67 ± 5.27 | 4.7 ± 2.9 | 12.0 | 12.5 | 0.95 |
| Olfactory cortex | 0.94 ± 0.11 | 1.02 ± 0.17 | 7.48 ± 10.44 | 8.6 ± 7.7 | 12.0 | 16.8 | 0.83 |
| Brain remnants | 1.20 ± 0.14 | 1.23 ± 0.15 | 2.81 ± 6.15 | 4.4 ± 4.3 | 11.7 | 12.1 | 0.94 |
| Mean ± SD | 4.14 ± 1.78 | 6.1 ± 2.1 | 10.7 ± 2.2 | 12.9 ± 2.8 | 0.85 ± 0.11 |
PET images were co-registered with an [11C]MPDX PET template in order to identify regions-of-interest
TRV test-retest variability, COV coefficient of variation, ICC intraclass correlation coefficient