Table 3.

Reliability of BP _ND calculated from a simplified reference tissue model (SRTM) fit, with the olfactory bulb as reference region

Region	Test	Retest	% relative difference	TRV	COV (%) test	COV (%) retest	ICC
Whole brain	0.70 ± 0.11	0.66 ± 0.07	−2.79 ± 16.20	10.8 ± 14.2	15.8	10.7	0.34
Amygdala	0.39 ± 0.38	0.18 ± 0.13	9.02 ± 40.92	31.4 ± 24.1	45.6	33.7	0.44
Caudate putamen	0.96 ± 0.93	0.17 ± 0.06	−1.68 ± 11.35	8.1 ± 8.6	17.6	7.0	0.69
Mesencephalic region	0.68 ± 0.64	0.12 ± 0.09	−3.68 ± 18.41	15.1 ± 12.1	17.3	13.5	0.13
Pons	0.51 ± 0.48	0.12 ± 0.09	−1.78 ± 26.39	22.5 ± 13.0	23.5	18.0	0.02
Medulla	0.40 ± 0.38	0.14 ± 0.08	5.81 ± 48.42	34.1 ± 28.9	35.6	21.2	*
Cerebellum	0.77 ± 0.73	0.10 ± 0.14	−3.72 ± 20.25	16.5 ± 14.5	12.8	19.2	0.34
Cortex	0.65 ± 0.61	0.11 ± 0.07	−4.39 ± 16.38	13.0 ± 12.9	16.3	11.4	0.24
Hippocampus	0.93 ± 0.90	0.18 ± 0.09	−1.46 ± 18.79	13.5 ± 14.8	19.5	10.3	0.24
Hypothalamus	0.45 ± 0.49	0.17 ± 0.19	13.17 ± 31.95	22.4 ± 16.7	37.0	38.8	0.73
Thalamus	1.14 ± 1.08	0.25 ± 0.09	−2.67 ± 19.54	14.4 ± 16.3	21.8	8.5	0.33
Olfactory cortex	0.48 ± 0.52	0.14 ± 0.16	10.10 ± 15.42	13.4 ± 8.7	28.5	29.8	0.93
Brain remnants	0.84 ± 0.81	0.12 ± 0.06	−1.82 ± 12.07	8.1 ± 9.6	14.9	7.8	0.51
Mean ± SD			1.09 ± 6.11	17.2 ± 8.2	23.6 ± 10.1	17.7 ± 10.5	0.41 ± 0.26

PET images were co-registered with a MRI template in order to identify regions-of-interest

TRV test-retest variability, COV coefficient of variation, ICC intraclass correlation coefficient

*ICC calculation gave an incorrect solution. N = 5