Table 3.

Comparison of EVs between preeclampsia and normotensive pregnancy

Parameter	Preeclampsia	Normotensive pregnancy	Reference
Total EVs	Increased/no change/decreased	Present	Tesse et al. [68]; Marques et al. [28]; Mikhailova et al. [33]; VanWijk et al. [69]; Holthe et al. [70]; Bretelle et al. [32]; Lok et al. [31]
Syncytiotrophoblast-derived EVs (early-onset PE)	Increased/no significant change	Present	Knight et al. [46]; Germain et al. [47•]; Goswami et al. [48]; Lok et al. [31]
Syncytiotrophoblast-derived EVs (late-onset PE)/severe	No change/no change	Present	Goswami et al. [48]; [28]
Endothelial cell-derived EVs	Increased/no change	Present	Marques et al. [28]; Gonzalez et al. [29]; VanWijk et al. [69]; Bretelle et al. [32]; Lok et al. [31]
Platelet-derived EVs	Decreased	Present	Marques et al. [28]; Bretelle et al.[32]; Lok et al.[28, 31]; Lok et al. [65]
Leukocyte-derived EVs	Increased	Present	Mikhailova et al. [33]; Marques et al. [28]
• Granulocyte-derived EVs	Increased	Present	Lok et al. [71]; vanWijk et al. [69]; Marques et al. [28]
• Monocyte-derived EVs	Increased	Present	Lok et al. [31, 71]; Marques et al.[28]
• Lymphocyte-derived EVs	Decreased	Present	Lok et al. [71]; Marques et al.[28]
• T cell-derived EVs	Increased	Negligible	vanWijk et al.[69]
• T helper cell-derived EVs	Increased	Negligible	Lok et al. [31]
Erythrocyte-derived EVs	Increased	Present	Lok et al. [31]; Marques et al. [28]; Dragovic et al. [64]