Table 4.
Saline-treated (n = 7) | MIA-treated (n = 9) | |||||
---|---|---|---|---|---|---|
AT-RvD1 | Morphine 1 μg | AT-RvD1 | Morphine 1 μg | |||
15 ng | 150 ng | 15 ng | 150 ng | |||
Aβ | 5 ± 7 | 6 ± 5 | 28 ± 6 | 1 ± 8 | 1 ± 9 | 2 ± 7# |
Aδ | −5 ± 10 | −10 ± 13 | 47 ± 7 | 11 ± 8 | 14 ± 10 | 40 ± 6 |
C | −4 ± 7 | −13 ± 9 | 60 ± 14 | 10 ± 7 | 3 ± 8 | 35 ± 8 |
PD | −6 ± 14 | −16 ± 15 | 70 ± 12 | 16 ± 24 | 9 ± 14 | 55 ± 9 |
Input | −5 ± 15 | −19 ± 21 | 71 ± 12 | −2 ± 12 | 2 ± 14 | 58 ± 11 |
WU | −12 ± 13 | −20 ± 16 | 62 ± 13 | 17 ± 19 | 12 ± 12 | 34 ± 6 |
Comparison of group effects of AT-RvD1 (15, 150 ng/50 μl) and morphine (1 μg/50 μl) on electrically evoked responses of spinal WDR neurones in MIA-treated rats versus saline-treated rats, expressed as % maximal inhibition. Note that negative values indicate facilitation
# p < 0.05 Mann-Whitney U test versus saline-treated rats