Fig. 3.

Insufficient erythropoietic output is a feature of Plasmodium cynomolgi B strain infection. a Reticulocyte Concentration of five rhesus macaques are shown prior to infection, during the acute primary, and after the peak of parasitemia. b Reticulocyte dynamics in relation to parasitemia for up to 100 days after inoculation are depicted. Orange bars indicate when peripheral blood and bone marrow aspirates were collected for retrospective systems biology analysis. c The relationship between hemoglobin and reticulocyte concentrations are shown for up to 100 days after inoculation. Statistical analysis was performed by a Friedman's Test with Dunn's multiple comparison post-hoc for Panel a; ^*p < 0.05, ns not significant