Table 2.
Severity and distribution of TDP-43-immunoreactive deposition
| Areas | Case 1 | Case 2 | Case 3 | Case 4 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NCI | Neurites | NNI | GCI | NCI | Neurites | NNI | GCI | NCI | Neurites | NNI | GCI | NCI | Neurites | NNI | GCI | |
| Basal ganglia | Basal forebrain; +++ | Basal forebrain; + | - | + | - | - | - | - | - | - | - | - | - | - | - | - |
| Temporal lobe | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Uncus | - | ++ | - | + | - | - | - | - | - | + | - | - | - | - | - | +/− |
| Hippocampus-PHG | CA1; +++ Subiculum; +++ Dentate fascia; +/− | CA1; +++ Subiculum; +++ | + | + | CA1; ++ subiculum++ Dentate fascia;+/− | CA1; ++ subiculum++ | - | + | - | - | - | - | - | - | - | - |
| Motor cortex | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Midbrain | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Medulla | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Spinal cord | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Abbreviations: GCI glial cytoplasmic inclusions, NCI neuronal cytoplasmic inclusion, NNI neuronal nuclear inclusion, PHG parahippocampal gyrus
-: none
+: mild
++: moderate
+++: severe