Table 4.

Multivariate linear regression of each heart rate variability parameter (dependent variable) with plasma cytokines (independent variables) at baseline

Independent variables	RMSSD		pNN50		HF		LF/HF
	p Value	β coefficient	p Value	β coefficient	p Value	β coefficient	p Value	β coefficient
Model I
IL-1RA	0.523	5.701	0.968	0.030	<0.001	−10.414	0.009	1.772
SCF	0.635	7.867	0.381	1.262	0.034	10.300	0.520	0.730
IFN-α	0.895	1.063	0.392	−0.602	0.739	−0.736	0.854	0.101
IP-10	0.762	5.658	0.725	0.567	0.001	19.838	0.005	−4.126
MIG	0.036	−34.531	0.072	−2.498	<0.001	−21.391	0.003	3.526
BLySa	0.598	8.028	0.411	−1.087	0.023	−10.276	0.110	1.724
Model II
IL-1RA	0.474	5.922	0.893	0.102	0.018	−8.913	0.039	1.555
SCF	0.559	9.075	0.384	1.259	0.185	8.802	0.488	0.927
IFN-α	0.867	1.262	0.414	−0.576	0.915	−0.336	0.949	0.041
IP-10	0.530	−8.722	0.618	−0.640	0.249	6.810	0.095	−2.070
sTNFRII	0.011	−51.594	0.078	−3.116	0.040	−16.762	0.061	3.100
BLySa	0.476	10.003	0.504	−0.867	0.229	−7.168	0.303	1.253

Abbreviations: BLyS B lymphocyte stimulator, HF high-frequency power, IFN interferon, IL interleukin, IL-1RA interleukin 1 receptor antagonist, IP-10 interferon gamma-induced protein 10, LF/HF low frequency to high frequency ratio, MIG monokine induced by interferon gamma, pNN50 percentage of pairs of adjacent NN intervals differing by more than 50 milliseconds, RMSSD square root of the mean of the squares of differences between adjacent NN intervals, SCF stem cell factor, sTNFRII soluble tumor necrosis factor receptor II

^aSerum BLyS

p values <0.05 are in bold type