Table 3.
Development of East Coast fever symptoms in cattle vaccinated with the multivalent antigen cocktail after exposure to Theileria parva-infected ‘low-line’ ticks
| Vaccinated cattle (n = 18) | Control cattle (n = 10) | P-value | ||
|---|---|---|---|---|
| Pyrexiaa,b | Number of animals where symptom observed (%) | 15 (83 %) | 9 (90 %) | < 0.999d |
| Day of first onset | 10.3 (1.2) | 11.1 (1.8) | 0.801e | |
| Duration | 5.8 (0.9) | 5. 6 (1.4) | 0.803e | |
| Regional lymph node parasitosisa | Number of animals where symptom observed (%) | 13 (72 %) | 9 (90 %) | 0.375d |
| Day of first onset | 13.5 (0.6) | 14.0 (1.1) | 0.774e | |
| Duration | 4.2 (0.7) | 3.7 (0.9) | 0.547e | |
| Contra-lateral lymph node parasitosisa | Number of animals developing symptom (%) | 8 (44 %) | 6 (60 %) | 0.695d |
| Day of first onset | 16.1 (0.5) | 17.2 (0.6) | 0.211e | |
| Duration | 3 (0.8) | 2.5 (1.7) | 0.825e | |
| Piroplasma | Number of animals where symptom observed (%) | 5 (28 %) | 4 (40 %) | 0.678d |
| Day of first onset | 17.6 (0.6) | 17.0 (0.4) | 0.722e | |
| Duration | 3 (0.6) | 3 (0.7) | < 0.999e | |
| Nested p104 PCR detection of parasites | 17 (94 %) | 9 (90 %) | < 0.999d | |
| PIM antibodies | Number of animals where antibodies detected (%) | 18 (100 %) | 10 (100 %) | < 0.999d |
| Average PP valuec | 44.7 ± 16.1 | 53.4 ± 22.8 | 0.249e |
aValues are displayed as the average day of first detection (SEM). Where symptoms were not observed in an animal, no values are reflected
bPyrexia was defined as rectal temperature exceeding 39.5 °C
cThe average Percentage Positive (PP) value calculated as the (OD of test sample/OD of strong positive) × 100
dFischer’s exact test
eMann-Whitney test