FIG 1.

Example of three HTS applications for infectious disease bacterial genomics. These applications use HTS data to answer common questions regarding bacterial pathogenesis in a public health/clinical microbiological research setting from bacterial typing to molecular epidemiology and in-depth pathogenomic investigations. These applications are shown in a feedback loop to demonstrate that HTS provides data that can be analyzed to various degrees (both depth and breadth) based on the hypotheses under test and the number of isolates included for comparative genomics.