TABLE 2.

T cell epitopes in humans and mice exposed to HMPV^a

HMPV protein	Epitope sequence	Species; MHC restriction	Cellular immunity generated	Mode(s) of antigen delivery	Reference(s)
N11–19	LSYKHAILK	Mouse; H2-Kb	TCD8, IFN-γ secretion	Experimental infection	160
N164–172	VGALIFTKL	Mouse; H-2Kb	CTLs, IL-12 and IFN-γ secretion	Peptide immunization	245
N198–206	YPRMDIPKI	Mouse; B7tg (restricted to HLA-B*0702)	Splenocytes, IFN-γ secretion	Experimental infection	160
M12–20	IPYTAAVQV	Human; HLA-B7	PBMCs, IFN-γ secretion; cytotoxicity	Natural viral infection	218
M94–112	VALDEYSKL	Mouse; H2-Kb and B7tg (restricted to HLA-B*0702)	CTLs, IFN-γ secretion	VLP vaccination	246
M194–203	IAPYAGLIMI	Human; HLA-B7, -B51, -B55	PBMCs, IFN-γ secretion; cytotoxicity	Natural viral infection	218
M195–203	APYAGLIM	Mouse; B7tg (restricted to HLA-B*0702)	Splenocytes, IFN-γ secretion	Experimental infection, VLP vaccination	160, 246
F528–536	SGVTNNGFI	Mouse; H2-Db	TCD8, CTLs, IFN-γ secretion	Experimental infection, VLP vaccination	160, 246
M2.181–89	GYIDDNQSI	Mouse; H-2Kd	Splenocytes, IFN-γ secretion	Experimental infection	222
M2.256–64	CYLENIEII	Mouse; H-2Kd	CTLs, IL-12 and IFN-γ secretion	Peptide immunization	245
SH35–44	KLILALLTFL	Human; HLA-A*0202	CTLs, IL-12 and IFN-γ secretion	Peptide immunization	245
G32–41	SLILIGITTL	Human; HLA-A*0201	CTLs, IL-12 and IFN-γ secretion	Peptide immunization	245

^aPBMCs, peripheral blood mononuclear cells; VLP, virus-like particle; TCD8, CD8⁺ T cells.