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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Brain Struct Funct. 2016 Mar 3;221(9):4691–4703. doi: 10.1007/s00429-016-1196-y

Figure 5.

Figure 5

Effect of trichostatin A (TSA) treatment on acetylated histone H3-K9&14 levels in the promoters of brain-derived neurotrophic factor (BDNF) exon I and IV in the whole hippocampus of adolescent intermittent ethanol (AIE) - and normal saline (AIS)-exposed adult rats as measured by the chromatin immunoprecipitation (ChIP) assay. Values are represented as the mean fold changes (±SEM) of 6 rats per group except in AIS+TSA group where 7 rats were used. *Significantly different from respective control groups [p<0.001, two-way ANOVA (AIE effect, F1,21= 1.5, p=0.24; TSA effect, F1,21= 6.1, p<0.05; AIE x TSA interaction, F1,21= 9.7, p<0.01) followed by Tukey’s test for BDNF exon I and p<0.01, two-way ANOVA (AIE effect, F1,21= 5.2, p<0.05; TSA effect, F1,21= 7.2, p<0.05; AIE x TSA interaction, F1,21= 3.9, p=0.06) followed by Tukey’s test for BDNF exon IV].