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(A) The general steps of chromosome conformation capture (3C), from left to right: covalent cross-linking of overlapping chromatin regions; chemical or auditory fragmentation; ligation of cross-linked segments; cross-link reversal and DNA purification. (B) Expansive methods of 3C that allow for higher processivity and more spatial information. Reprinted (adapted or reprinted in part) with permission from ref 152. Copyright 2014 BioMed Central Ltd.
