Table 3.
Results for 15 CRC susceptibility SNPs in patients with ≥100 polyps and <100 polyps, under a codominant inheritance model
| SNP | Chromosome position | Genotype | Total (%) | ≥100 polyps (%) | Odds ratio | 95 % CI | p value Wald 1 df | p value Wald 2 df |
|---|---|---|---|---|---|---|---|---|
| rs6691170 | 1q41 | 410 (100) | 182 | 0.96 | ||||
| GG | 195 (47.6) | 86 (47.3) | 1 | |||||
| TG | 167 (40.7) | 74 (40.7) | 1.03 | 0.68–1.56 | 0.89 | |||
| TT | 48 (11.7) | 22 (12.0) | 1.01 | 0.57–2.13 | 0.78 | |||
| rs6687758 | 1q41 | 419 (100) | 188 | 0.35 | ||||
| AA | 300 (71.6) | 133 (70.7) | 1 | |||||
| GA | 104 (24.8) | 46 (24.5) | 2.42 | 0.71–1.87 | 0.56 | |||
| GG | 15 (3.6) | 9 (4.8) | 2.10 | 0.72–8.17 | 0.16 | |||
| rs10936599 | 3q26.2 | 410 (100) | 180 | 0.39 | ||||
| TT | 21 (5.1) | 10 (5.5) | 1 | |||||
| TC | 146 (35.6) | 68 (37.8) | 0.99 | 0.46–2.13 | 0.98 | |||
| CC | 243 (59.3) | 102 (56.7) | 0.76 | 0.35–1.65 | 0.49 | |||
| rs16892766 | 8q23.3 | 417 (100) | 187 | |||||
| AA | 343 (82.3) | 146 (78.1) | 1 | |||||
| CA and CCa | 74 (17.7) | 41 (21.9) | 1.71 | 1.05–2.76 | 0.03 | |||
| [CC] | [2] | [2] | ||||||
| rs6983267 | 8q24.21 | 408 (100) | 179 | 0.32 | ||||
| TT | 92 (22.5) | 45 (25.1) | 1 | |||||
| TG | 192 (47.1) | 84 (46.9) | 0.77 | 0.43–1.40 | 0.40 | |||
| GG | 124 (30.4) | 50 (27.9) | 0.64 | 0.36–1.14 | 0.13 | |||
| rs10795668 | 10p14 | 417 (100) | 187 | 0.98 | ||||
| AA | 33 (7.9) | 14 (7.5) | 1 | |||||
| GA | 193 (46.3) | 85 (45.4) | 0.99 | 0.49–1.98 | 0.97 | |||
| GG | 191 (45.8) | 88 (47.1) | 0.95 | 0.46–1.94 | 0.88 | |||
| rs3802842 | 11q23.1 | 415 (100) | 185 | 0.02 | ||||
| AA | 226 (54.5) | 91 (49.2) | 1 | |||||
| CA | 158 (38.1) | 84 (45.4) | 1.70 | 1.13–2.55 | 0.01 | |||
| CC | 31 (7.5) | 10 (5.4) | 0.76 | 0.34–1.68 | 0.49 | |||
| rs7136702 | 12q13.13 | 413 (100) | 185 | 0.65 | ||||
| CC | 175 (42.4) | 82 (44.3) | 1 | |||||
| TC | 190 (46.0) | 84 (45.4) | 0.94 | 0.60–1.46 | 0.78 | |||
| TT | 48 (11.6) | 19 (10.3) | 0.75 | 0.42–1.37 | 0.35 | |||
| rs11169552 | 12q13.13 | 415 (100) | 185 | 0.97 | ||||
| CC | 237 (57.1) | 106 (57.3) | 1 | |||||
| TC | 151 (36.4) | 68 (36.8) | 1.01 | 0.61–1.68 | 0.97 | |||
| TT | 27 (6.5) | 11 (5.9) | 0.93 | 0.45–1.93 | 0.84 | |||
| rs4444235 | 14q22.2 | 415 (100) | 184 | 0.97 | ||||
| TT | 128 (30.8) | 57 (31.0) | 1 | |||||
| CT | 215 (51.8) | 94 (51.1) | 1.01 | 0.65–1.58 | 0.96 | |||
| CC | 72 (17.3) | 33 (17.9) | 0.95 | 0.53–1.69 | 0.85 | |||
| rs4779584 | 15q13.3 | 411 (100) | 183 | 0.27 | ||||
| CC | 290 (70.6) | 123 (67.2) | 1 | |||||
| CT | 111 (27.0) | 57 (31.1) | 1.77 | 0.60–5.22 | 0.30 | |||
| TT | 10 (2.4) | 3 (1.6) | 1.28 | 0.42–3.86 | 0.67 | |||
| rs9929218 | 16q22.1 | 415 (100) | 186 | 0.66 | ||||
| AA | 34 (8.2) | 12 (6.5) | 1 | |||||
| GA | 184 (44.3) | 86 (46.2) | 1.36 | 0.68–2.73 | 0.39 | |||
| GG | 197 (47.5) | 88 (47.3) | 1.22 | 0.59–2.52 | 0.60 | |||
| rs10411210 | 19q13.11 | 418 (100) | 188 | 0.83 | ||||
| TT | 11 (2.6) | 5 (2.7) | 1 | |||||
| CT | 84 (20.1) | 33 (17.6) | 0.90 | 0.25–3.22 | 0.88 | |||
| CC | 323 (77.3) | 150 (79.8) | 1.05 | 0.32–3.46 | 0.93 | |||
| rs961253 | 20p12.3 | 412 (100) | 184 | 0.29 | ||||
| CC | 202 (49.0) | 94 (51.0) | 1 | |||||
| CA | 164 (39.8) | 75 (40.8) | 1.00 | 0.62–1.63 | 0.99 | |||
| AA | 46 (11.2) | 15 (8.2) | 0.64 | 0.35–1.16 | 0.14 | |||
| rs4925386 | 20q13.33 | 413 (100) | 182 | 0.10 | ||||
| TT | 43 (10.4) | 18 (9.9) | 1 | |||||
| TC | 171 (41.4) | 83 (45.6) | 1.15 | 0.61–2.17 | 0.66 | |||
| CC | 199 (48.2) | 81 (44.5) | 0.77 | 0.39–1.51 | 0.44 |
aDue to the low frequency, the CC genotype of rs16892766 could not be assessed; the CC and CA genotypes were combined for this SNP