Fig. 4.—
Gene pathways related to forebrain development in budgerigar lineage-specific EBRs and avian and archosaurian msHSBs. Budgerigar lineage-specific EBRs (top box) are enriched for genes related to the NOTCH1-NUMB pathway, while avian and archosaurian msHSBs (bottom box) for genes related to three conserved canonical pathways (SHH pathway in blue, WNT3 pathway in pink and FGF8 pathway in purple). The function of each protein is indicated in the legend by different shapes and colours. Red lines connecting two proteins indicate inhibition, while blue lines show activation. The green circular shade represents the cell membrane, while the orange circular shade demarcates the nuclear envelope. The image was modified from Metacore version 6.22 build 67265 and Bertrand and Dahmane (2006).
