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. 2016 Jul 10;8(8):2459–2473. doi: 10.1093/gbe/evw168

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© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 1.— — A hypothetical cell type tree for ESF. The tree contains two kinds of inner nodes. One that represents cell type origination events, black ovals, and the other represents species lineage splits, white ovals. In this tree paleo-ESF originate from a cell type splitting event with FDC and the extant paleo ESF in this diagram is related to the neo-ESF/DSC pair by the species lineage splitting event that gave rise to the marsupial and the eutherian stem lineages. The neo-ESF/DSC sister cell type pair arose in the stem lineage of eutherian mammals. The arrow represents the ontogenetic transformation of ESF into DSC.