Skip to main content
. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mol Cancer Ther. 2016 Jun 15;15(9):2055–2065. doi: 10.1158/1535-7163.MCT-15-1023

Figure 3. In vitro IRE1α ribonuclease assay on a selection of acridine derivatives.

Figure 3

Top: splicing of radio-labelled full-length human XBP1 mRNA by recombinant hIRE1α (far left) and the effects of increasing doses of the 4 acridine derivatives on the splicing. Bottom: splicing of radio-labelled full-length human BLOS1 mRNA by recombinant hIRE1α (far left) and the effects of increasing doses of the 4 acridine derivatives on the splicing.