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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: J Immunol. 2016 Aug 17;197(6):2522–2531. doi: 10.4049/jimmunol.1600915

Figure 9. Schematic representation of IgM and IgD isotype functions.

Figure 9

IgM and IgD isotype stimulation triggers very distinct signaling outcomes. IgM induces prolonged signaling activation, and is mainly responsible for CLL survival and chemokine secretion. IgD receptors, which are structurally very similar to IgM, induce strong activation of proximal signaling proteins and of the cytoskeleton, but are rapidly internalized following stimulation and fail to activate downstream responses. VH: variable region of the heavy chain; CH: constant region of the heavy chain; VL: variable region of the light chain; CL: constant region of the light chain.